To summarize the nursing experience of a case of acute lymphoblastic leukemia complicated with inguinal necrotizing fasciitis. Nursing points include：to fully evaluate the wound condition,a variety of debridement methods combined with the removal of wound necrotic tissue;the negative pressure technique of wound perfusion was used to control wound infection;secondary wound suture was performed as soon as possible;the use of wet dressings to promote residual wound healing;scientific management of urine and feces to avoid contamination of the wound;personalized nutrition solution is prepared to provide adequate nutrition support. After active treatment and careful nursing care,the patient’s condition was stable. 83 days later,the wound healed and the second stage chemotherapy was continued.